I was getting as 0x80040E21 error on a SSIS 2005 package when exporting some rows to an Excel file.
In my case this was caused by an input column of the type varchar(max) after converting this column in my t-sql query to a varchar(1024) column the error was resolved.
Error: 0xC0202009 at Data Flow Task, Excel Destination : SSIS Error Code DTS_E_OLEDBERROR. An OLE DB error has occurred. Error code: 0x80040E21.
Error: 0xC0202025 at Data Flow Task, Excel Destination : Cannot create an OLE DB accessor. Verify that the column metadata is valid.
Error: 0xC004701A at Data Flow Task, DTS.Pipeline: component "Excel Destination" (16) failed the pre-execute phase and returned error code 0xC0202025.